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KMID : 1130320160590050231
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Korean Journal of Pediatrics
2016 Volume.59 No. 5 p.231 ~ p.238
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Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents
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Kim Ki-Eun
Cho Young-Sun
Baek Kyung-Suk
Lan Li
Baek Kwang-Hyun
Kim Jung-Hyun
Kim Ho-Seong
Sheen Youn-Ho
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Abstract
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Purpose: Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/ obese and normal-weight adolescents and to assess the correlation of circulating LBP levels with anthropometric measures and obesity-related biomarkers, including insulin resistance, liver enzyme levels, and lipid profiles.
Methods: The study included 87 adolescents aged 12?13 years; 44 were overweight/obese and 43 were of normal-weight. We assessed anthropometric and laboratory measures, including body mass index (BMI), blood pressure, insulin sensitivity, liver enzyme levels, and lipid profiles. Plasma LBP levels were measured using an enzyme-linked immunosorbent assay.
Results: The mean age of the participants was 12.9±0.3 years. Circulating plasma LBP levels were significantly increased in overweight/obese participants compared with those in normal-weight participants (P<0.0001). LBP levels were significantly and positively associated with BMI; systolic and diastolic blood pressure; total cholesterol, low density lipoprotein-cholesterol, triglyceride, aspartate aminotransferase, and alanine aminotransferase levels; and insulin resistance as indicated by the homeostasis model assessment of insulin resistance (HOMA-IR) (all P<0.05). In multivariate linear regression analysis, BMI and HOMA-IR were independently and positively associated with plasma LBP levels.
Conclusion: LBP is an inflammatory biomarker associated with BMI and obesity-related insulin resistance in adolescents. The positive correlation between these parameters suggests a potentially relevant pathophysiological mechanism linking LBP to obesity-related insulin resistance in adolescents.
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KEYWORD
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Lipopolysaccharide-binding protein , Body mass index , Insulin resistance , Adolescent , Obesity
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